More positive health findings tied to the famed cannabis plant. European researchers believe that the cannabis compound cannabidiol (CBD) may have antipsychotic properties. Cannabidiol is a key constituent of the cannabis plant and is second only to THC. Though the use of cannabis has been associated with an increased risk of developing psychosis, CBD seems to have the opposite effect and may be helpful in the treatment of conditions such as anxiety disorders, bipolar disorders and Schizophrenia. You will find a summary of the findings below.
Cananbidiol (CBD), a non-psychotropic cannabinoid, alleviates psychotic symptoms and may hold promise as an alternative antipsychotic treatment, according to a review published in the November issue of the journal Neuropsychopharmacology.
Investigators in the Netherlands and in the United Kingdom reviewed preclinical and clinical data on the use of CBD as an antipsychotic agent. Authors reported that both animal and human studies document the ability of CBD to mitigate symptoms of psychosis. Specifically, CBD administration is associated with improved symptoms in clinical evaluations of patients with schizophrenia, Parkinson’s disease, and ketamine-induced dissociative and psychotic symptoms.
Investigators also highlighted a 2012 double-blind, randomized placebo-controlled trial assessing CBD versus the prescription anti-psychotic drug amisulpride in 42 subjects with schizophrenia and acute paranoia. Authors reported that both CBD and the prescription drug were associated with “equally significant clinical improvement” in this patient population, but that cannabidiol “possessed significantly less side effects.”
Researchers concluded: “Evidence from several study domains suggests that CBD has some potential as an antipsychotic treatment. … Given the high tolerability and superior cost-effectiveness, CBD may prove to be an attractive alternative to current antipsychotic treatment.”
Previous human trials assessing the administration of CBD in healthy human subjects report that the cannabinoid is “safe and well tolerated.”
Separate investigations of CBD, primarily in animal models, have documented the cannabinoid to possess a variety of therapeutic qualities, including anti-inflammatory, anti-diabetic, anti-epileptic, anti-cancer, and bone-stimulating properties. Recently, the FDA approved the experimental use of CBD extracts for the treatment of a rare form of intractable pediatric epilepsy known as Dravet syndrome. Preliminary clinical trials assessing the safety and tolerability of the compound in children are scheduled to begin imminently.
Detailed text of the findings, titled “Cannabidiol as a potential treatment for psychosis,” published by the European Neuropsychopharmacology.